Self-organization and culture of Mesenchymal Stem Cell

In recent years, 3D cell culture models such as spheroid or organoid technologies have known important developments. Many studies have shown that 3D cultures exhibit better biomimetic properties compared to 2D cultures. These properties are important for in-vitro modeling systems, as well as for in-vivo cell therapies and tissue engineering approaches. A reliable use of 3D cellular models still requires standardized protocols with well-controlled and … Continue reading Self-organization and culture of Mesenchymal Stem Cell

Production of itaconic acid from alkali pretreated lignin by dynamic two stage bioconversion

Expanding the portfolio of products that can be made from lignin will be critical to enabling a viable bio-based economy. Here, we engineer Pseudomonas putida for high-yield production of the tricarboxylic acid cycle-derived building block chemical, itaconic acid, from model aromatic compounds and aromatics derived from lignin. We develop a nitrogen starvation-detecting biosensor for dynamic two-stage bioproduction in which itaconic acid is produced during a non-growth associated … Continue reading Production of itaconic acid from alkali pretreated lignin by dynamic two stage bioconversion

J&J in talks with Modi govt to start clinical trials for its single-shot Covid vaccine in India

New Delhi: US pharma giant Johnson & Johnson has said it is in talks with the Modi Johnson has said it is in talks with the Modi government to start clinical trials for its single-shot Covid-19 vaccine in India. The company has informed the Central Drugs Standard Control Organisation (CDSCO), the Indian drug regulator, about its plan to start “bridging clinical trials” soon. The move will help India ramp up the vaccination drive … Continue reading J&J in talks with Modi govt to start clinical trials for its single-shot Covid vaccine in India

Search Indigenous System for Assessment and Relearning of Postural Balance

Postural stability is achieved by maintaining an upright body alignment against gravitational force and preserving the equilibrium of the Centre of Pressure (CoP) in an individual’s base of support. Successful postural control requires contribution from a complex sensory system comprising visual, somatosensory and vestibular modalities as well as motor control systems.  Due to recent technological advances, a growing trend in balance assessments has become the … Continue reading Search Indigenous System for Assessment and Relearning of Postural Balance

Combating Multi-drug Resistant Malaria Parasite

Malaria is one of the major parasitic diseases in tropical and subtropical regions which is caused by the genus Plasmodium and transmitted to human beings through the bites of female Anopheles sp. mosquitoes. About 40% of the world’s population lives in malaria-endemic areas. It causes about 1 million deaths per year globally. The situation gets worsened by the widespread development of parasite lines becoming resistant … Continue reading Combating Multi-drug Resistant Malaria Parasite

Parallel nuclear magnetic resonance spectroscopy

Nuclear magnetic resonance (NMR) spectroscopy is a principal analytical technique used for the structure elucidation of molecules. This Primer covers different approaches to accelerate data acquisition and increase sensitivity of NMR measurements through parallelization, enabled by hardware design and/or pulse sequence development. Starting with hardware-based methods, we discuss coupling multiple detectors to multiple samples so each detector/sample combination provides unique information. We then cover spatio-temporal … Continue reading Parallel nuclear magnetic resonance spectroscopy

Scopolamine promotes neuroinflammation

Postoperative delirium is a common neuro psychiatric syndrome resulting a high postsurgical mortality rate and decline in postdischarge function. Extensive research has been performed on both human and animal delirium-like models due to their clinical significance, focusing on systematic inflammation and consequent neuroinflammation playing a key role in the pathogenesis of postoperative cognitive dysfunctions. Since animal models are widely utilized for pathophysiological study of neuropsychiatric … Continue reading Scopolamine promotes neuroinflammation

CSIR Young Scientist Award 2020

The Council of Scientific & Industrial Research introduced, in 1987, a scheme of awards for Young Scientists in the CSIR system in order to promote excellence in various fields of science and technology. The awards are known as “CSIR Young Scientist Awards”. CSIR scientist, below 35 years of age, as reckoned on 26 September (CSIR Foundation Day) of the preceding year, is eligible for the … Continue reading CSIR Young Scientist Award 2020

Below 3 Å structure of apoferritin using a multipurpose TEM

This study is all about the structural analysis of protein complexes by cryo-electron microscopy (cryo-EM) single particle analysis (SPA) has had great impact as a biophysical method. Many results of cryo-EM SPA are based on data acquired on state-of-the-art cryo-electron microscopes customized for SPA. These are currently only available in limited locations around the world, where securing machine time is highly competitive. One potential solution for … Continue reading Below 3 Å structure of apoferritin using a multipurpose TEM

A decadal perspective on north water microbial eukaryotes

The North Water region, between Greenland and Ellesmere Island, with high populations of marine birds and mammals, is an Arctic icon. Due to climate related changes, seasonal patterns in water column primary production are changing but the implications for the planktonic microbial eukaryote communities that support the ecosystem are unknown. Here we report microbial community phenology in samples collected over 12 years (2005–2018) from July to … Continue reading A decadal perspective on north water microbial eukaryotes