Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue

Later stages of secondary lymphedema are associated with the massive deposition of adipose tissue (AT). The factors driving lymphedema-associated AT (LAT) expansion in humans remain rather elusive. We hypothesized that LAT expansion could be based on alterations of metabolic, adipogenic, immune and/or angiogenic qualities of AT. AT samples were acquired from upper limbs of 11 women with unilateral breast cancer-related lymphedema and 11 healthy women … Continue reading Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue

Recent study explains how the human brain recognizes jumbled words

Our brains are quite proficient at recognizing jumbled words and reading them correctly. Researchers from the Indian Institute of Science, Bengaluru, studied this fascinating phenomenon and came up with a computational model that uses artificial neurons to simulate the way the brain processes jumbled words. How does our brain read jumbled words correctly? Scientists led by SP Arun and K V S Hari from the Centre for Neuroscience, … Continue reading Recent study explains how the human brain recognizes jumbled words

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

The global emergence of SARS-CoV-2 urgently requires an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several individual omics studies have extended our knowledge of COVID-19 pathophysiology1–10. Integration of such datasets to obtain a holistic view of virus-host interactions and to define the pathogenic properties of SARS-CoV-2 is limited by the heterogeneity of the experimental systems. We therefore … Continue reading Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Advances in healthcare wearable devices

Wearable devices have found numerous applications in healthcare ranging from physiological diseases, such as cardiovascular diseases, hypertension and muscle disorders to neurocognitive disorders, such as Parkinson’s disease, Alzheimer’s disease and other psychological diseases. Different types of wearables are used for this purpose, for example, skin-based wearables including tattoo-based wearables, textile-based wearables, and biofluidic-based wearables. Recently, wearables have also shown encouraging improvements as a drug delivery … Continue reading Advances in healthcare wearable devices

Insights into intrauterine growth restriction based on maternal

Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (1H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and … Continue reading Insights into intrauterine growth restriction based on maternal

Cell-programmed nutrient partitioning in the tumour microenvironment

Cancer cells characteristically consume glucose through Warburg metabolism1, a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metabolism in the tumour microenvironment (TME) contributes to immune evasion by tumour cells. However, whether the metabolism of immune cells is dysregulated in the TME by cell-intrinsic programs or by competition with … Continue reading Cell-programmed nutrient partitioning in the tumour microenvironment

CGRP protects bladder smooth muscle cells stimulated

This study aimed to explore the effect of calcitonin gene-related peptide (CGRP) on bladder smooth muscle cells (BSMCs) under high glucose (HG) treatment in vitro. BSMCs from Sprague–Dawley rat bladders were cultured and passaged in vitro. The third-generation cells were cultured and divided into control group, HG group, HG + CGRP group, HG + CGRP + asiatic acid (AA, p-p38 activator) group, CGRP group, AA group, HG + CGRP + CGRP-8-37 (CGRP receptor antagonist) group … Continue reading CGRP protects bladder smooth muscle cells stimulated

Physiological clearance of amyloid-beta by the kidney

The researcher studied about   Amyloid-β (Aβ) accumulation in the brain is a pivotal event in the pathogenesis of Alzheimer’s disease (AD), and its clearance from the brain is impaired in sporadic AD. Previous studies suggest that approximately half of the Aβ produced in the brain is cleared by transport into the periphery. However, the mechanism and pathophysiological significance of peripheral Aβ clearance remain largely … Continue reading Physiological clearance of amyloid-beta by the kidney

Identification of blood-derived candidate gene markers and a new 7-gene

Multiple sclerosis (MS), which is a chronic inflammatory disease at the central nervous system of autoimmune etiology, is characterized by varying degrees of demyelination and axonal loss. MS predominantly affects young women (between the ages of 20 and 40) and is a leading cause of disability among young adults in the United States. About 2.5 million cases have been reported all over the world, with … Continue reading Identification of blood-derived candidate gene markers and a new 7-gene

T cell assays differentiate clinical and subclinical SARS-CoV-2

Identification of protective T cell responses against SARS-CoV-2 requires distinguishing people infected with SARS-CoV-2 from those with cross-reactive immunity to other coronaviruses. Here we show a range of T cell assays that differentially capture immune function to characterise SARS-CoV-2 responses. Strong ex vivo ELISpot and proliferation responses to multiple antigens (including M, NP and ORF3) are found in 168 PCR-confirmed SARS-CoV-2 infected volunteers, but are … Continue reading T cell assays differentiate clinical and subclinical SARS-CoV-2