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Biofilm production and antimicrobial susceptibility pattern among urinary isolates

Urinary tract infection is the most commonly acquired bacterial infection. Bacterial biofilms play an important role in UTI and are responsible for persistent infections as well as higher antimicrobial resistance. The microorganisms in the biofilms are difficult to treat with antimicrobial agents causing public health problem.  Aerobic bacterial isolates from urine samples submitted to microbiology laboratory.The isolates were tested for biofilm formation by Congo red agar … Continue reading Biofilm production and antimicrobial susceptibility pattern among urinary isolates

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Shorter Treatment for Nonsevere Tuberculosis

Two thirds of children with tuberculosis have nonsevere disease, which may be treatable with a shorter regimen than the current 6-month regimen. The trial involving children with nonsevere, symptomatic, presumably drug-susceptible, smear-negative tuberculosis in Uganda, Zambia, South Africa, and India with under 16 years of age were randomly assigned to 16 weeks or 24 weeks of standard first-line antituberculosis treatment with pediatric fixed-dose combinations as recommended … Continue reading Shorter Treatment for Nonsevere Tuberculosis

Advances in breast cancer radiotherapy

Breast cancer is the most common cancer among women in India, and about 160,000 cases are diagnosed annually. Advances in technology, as well as our understanding of breast cancer biology, coupled with an increasing emphasis on early detection, have resulted in improved outcomes for breast cancer patients. Here, an attempt was made to review the recent advances made in adjuvant radiotherapy of breast cancer. Technological … Continue reading Advances in breast cancer radiotherapy

Visualising Viruses

Viruses pose a challenge to our imaginations. The structures of some virus particles have been determined experimentally in great detail, but for many important viruses a detailed description of the virus particle is lacking. This can be because they are challenging to describe with a single experimental method, or simply because of a lack of data. In these cases, methods from medical illustration can be applied … Continue reading Visualising Viruses

Detection of invasive Trichosporon asahii in patient blood by a fungal PCR array

Immunosuppression due to medical therapy has extended life expectancy of patients with previously fatal diseases and is therefore playing a crucial role in the increasing incidence of invasive fungal infections .  Globally, invasive trichosporonosis is reported to be the second most common non-candida yeast infection in patients suffering from haematological malignancies, oftentimes leading to fatal outcomes despite appropriate therapy . Herein, we report on a retrospectively applied experimental diagnostic fungal … Continue reading Detection of invasive Trichosporon asahii in patient blood by a fungal PCR array

Spatiotemporal proteomic profiling of the pro-inflammatory response

Protein localisation and translocation between intracellular compartments underlie almost all physiological processes. The hyperLOPIT proteomics platform combines mass spectrometry with state-of-the-art machine learning to map the subcellular location of thousands of proteins simultaneously. We combine global proteome analysis with hyperLOPIT in a fully Bayesian framework to elucidate spatiotemporal proteomic changes during a lipopolysaccharide (LPS)-induced inflammatory response. We report a highly dynamic proteome in terms of … Continue reading Spatiotemporal proteomic profiling of the pro-inflammatory response

Y chromosome plays vital role in evolution

A study conducted by the CSIR-CCMB has given fresh insights into the role played by the Y chromosome in the DNA. The study done by a team of researchers headed by Professor Rachel Jesudasan, Advisor (Research) at the Department Genetics of Osmania University, throws light on novel regulatory functions of the Y chromosome. Published in BMC Biology, the research suggests that beyond determining the gender … Continue reading Y chromosome plays vital role in evolution

Importance of crop phenological stages

During the last decades, the incorporation of beneficial microorganisms in agriculture crop management has become a common practice. Seed coating of these microorganisms still faces technical issues, which limit its implementation in conventional agriculture. An adaption to widely established agricultural practices, e.g. fertigation, could help to overcome these issues. Here, using Bacillus velezensis strain BBC047, we show the influence of the crop phenological stages on the efficiency … Continue reading Importance of crop phenological stages

Chromosome-level genome assemblies of five Prunus species

Prunus species include many important perennial fruit crops, such as peach, plum, apricot, and related wild species. Here, we report de novogenome assemblies for five species, including the cultivated species peach (Prunus persica), plum (Prunus salicina), and apricot (Prunus armeniaca), and the wild peach species Tibetan peach (Prunus mira) and Chinese wild peach (Prunus davidiana). The genomes ranged from 240 to 276 Mb in size, with contig N50 … Continue reading Chromosome-level genome assemblies of five Prunus species

Molecular mechanisms of inhibiting glucosyltransferases

Glucosyltransferases (Gtfs) play critical roles in the etiology and pathogenesis of Streptococcus mutans (S. mutans)- mediated dental caries including early childhood caries. Gtfs enhance the biofilm formation and promotes colonization of cariogenic bacteria by generating biofilm extracellular polysaccharides (EPSs), the key virulence property in the cariogenic process. Therefore, Gtfs have become an appealing target for effective therapeutic interventions that inhibit cariogenic biofilms. Importantly, targeting Gtfs selectively impairs … Continue reading Molecular mechanisms of inhibiting glucosyltransferases