
A collagen glucosyltransferase drives lung adenocarcinoma
In this research scientist study about Cancer cells. They are a major source of enzymes that modify collagen to create a stiff, fibrotic tumor stroma. High collagen lysyl hydroxylase 2 (LH2) expression promotes metastasis and is correlated with shorter survival in lung adenocarcinoma (LUAD) and other tumor types. LH2 hydroxylates lysine (Lys) residues on fibrillar collagen’s amino- and carboxy-terminal telopeptides to create stable collagen cross-links. … Continue reading A collagen glucosyltransferase drives lung adenocarcinoma