
Membrane targeting drugs polymyxin and lipopeptide.
The classe of antibiotics, membrane-targeting drugs of last resort i.e. polymyxin and lipopeptide used to treat infections caused by multi-drug-resistant pathogens. Polymyxins treat infections caused by carbapenem-resistant species such as Escherichia coli , Acinetobacter baumannii and Pseudomonas aeruginosa by targeting the membrane consist of lipopolysaccharide of most Gram negative species . By contrast, the lipopeptide daptomycin requires membrane phosphatidylglycerol for activity and is only used to treat infections … Continue reading Membrane targeting drugs polymyxin and lipopeptide.