ENVIRONMENT

Nanosilica modified with polyaspartic acid as an industrial circulating

Given the special performance of nanosilica with its small size, large specific surface area and high surface activity, nanosilica containing reactive amino group (denoted as SiO2–NH2) and polysuccinimide were allowed to take part in polymerization reaction to afford SiO2–NH2modified polyaspartic acid (denoted as SiO2–NH2/PASP), a potential polymer scale inhibitor with good water solubility for industrial circulating water. The scale inhibition performance of the as-prepared SiO2–NH2/PASP … Continue reading Nanosilica modified with polyaspartic acid as an industrial circulating

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OPPORTUNITIES

Application Process and Important Instructions – CSIR-AMPRI

CSIR- Advanced Materials & Processes Research Institute (AMPRI), Bhopal [A constituent laboratory of Council of Scientific and Industrial Research (CSIR), an Autonomous body under Ministry of Science & Technology and Earth Sciences, Govt. of India] is one of the premier R&D Institutions in the country dedicated in conducting high-quality research in the area of Advanced Materials and is engaged in developing promising technologies. Important Date: … Continue reading Application Process and Important Instructions – CSIR-AMPRI

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MEDICAL SCIENCE

Multi-region exome sequencing reveals the intratumoral heterogeneity

Small cell lung cancer (SCLC) is a highly malignant tumor which is eventually refractory to any treatment. Intratumoral heterogeneity (ITH) may contribute to treatment failure. However, the extent of ITH in SCLC is still largely unknown. Here, we subject 120 tumor samples from 40 stage I-III SCLC patients to multi-regional whole-exome sequencing. The most common mutant genes are TP53 (88%) and RB1 (72%). We observe … Continue reading Multi-region exome sequencing reveals the intratumoral heterogeneity

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MEDICAL SCIENCE

A prostate-specific membrane antigen activated molecular rotor

Surgery is an efficient way to treat localized prostate cancer (PCa), however, it is challenging to demarcate rapidly and accurately the tumor boundary intraoperatively, as existing tumor detection methods are seldom performed in real-time. To overcome those limitations, we develop a fluorescent molecular rotor that specifically targets the prostate-specific membrane antigen (PSMA), an established marker for PCa. The probes have picomolar affinity (IC50 = 63-118 pM) for … Continue reading A prostate-specific membrane antigen activated molecular rotor

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PHYSICAL & CHEMICAL SCIENCE

Color coding molecular mirror images

Enantiomers are molecules that are each other’s mirror image—like one’s left and right hand. They are said to be chiral, chirality being the term for ‘displaying handedness.” Although a pair of enantiomers have totally the same chemical and physical properties, they often exhibit different physiological activity towards biological molecules. Being able to distinguish between enantiomers and detect chirality is important for pharmaceutical purposes—often, only one of … Continue reading Color coding molecular mirror images

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PHYSICAL & CHEMICAL SCIENCE

A scalable workflow to characterize the human exposome

Complementing the genome with an understanding of the human exposome is an important challenge for contemporary science and technology. Tens of thousands of chemicals are used in commerce, yet cost for targeted environmental chemical analysis limits surveillance to a few hundred known hazards. To overcome limitations which prevent scaling to thousands of chemicals, we develop a single-step express liquid extraction and gas chromatography high-resolution mass … Continue reading A scalable workflow to characterize the human exposome

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BIOLOGICAL SCIENCE

Molecular basis for PICS-mediated piRNA biogenesis and cell division

By incorporating two mutually exclusive factors, PID-1 and TOST-1, C. elegans PICS complex plays important roles in piRNA biogenesis, chromosome segregation and cell division. We firstly map the interaction network between PICS subunits, then uncover the mechanisms underlying the interactions between PICS subunits by solving several complex structures, including those of TOFU-6/PICS-1, ERH-2/PICS-1, and ERH-2/TOST-1. Our biochemical experiment also demonstrates that PICS exists as an octamer consisting … Continue reading Molecular basis for PICS-mediated piRNA biogenesis and cell division

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BIOLOGICAL SCIENCE

Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis

The discovery of Acanthamoeba polyphaga Mimivirus, the first isolated giant virus of amoeba, challenged the historical hallmarks defining a virus. Giant virion sizes are known to reach up to 2.3 µm, making them visible by optical microscopy. Their large genome sizes of up to 2.5 Mb can encode proteins involved in the translation apparatus. We have investigated possible energy production in Pandoravirus massiliensis. Mitochondrial membrane markers allowed for the detection … Continue reading Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis

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ENVIRONMENT

Influence of storms on the emission of pollutants from sewage into waters

Fig: Arrangement of rain gauges and storm overflows on the sewage network in the area of the considered catchment. OS-1 ÷ 3—overflow structures; 1–6—rain gauges; STP—sewage treatment plant. During heavy precipitation, chemical and biological pollutants from urban and agricultural areas enter the waters from storm overflows as a result of infiltration and inflow, as well as via uncontrolled outflows from water treatment plants. Infiltration and inflow of … Continue reading Influence of storms on the emission of pollutants from sewage into waters

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PHYSICAL & CHEMICAL SCIENCE

Liquid condensation of reprogramming factor KLF4 with DNA

FIG: KLF4 forms a condensed liquid phase in HEK 293T cells and BJ fibroblasts Expression of a few master transcription factors can reprogram the epigenetic landscape and three-dimensional chromatin topology of differentiated cells and achieve pluripotency. During reprogramming, thousands of long-range chromatin contacts are altered, and changes in promoter association with enhancers dramatically influence transcription. Molecular participants at these sites have been identified, but how this … Continue reading Liquid condensation of reprogramming factor KLF4 with DNA

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