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Membrane targeting drugs polymyxin and lipopeptide.

The classe of antibiotics, membrane-targeting drugs of last resort i.e. polymyxin and lipopeptide used to treat infections caused by multi-drug-resistant pathogens. Polymyxins treat infections caused by carbapenem-resistant species such as Escherichia coli , Acinetobacter baumannii and Pseudomonas aeruginosa  by targeting the membrane consist of lipopolysaccharide of most Gram negative species . By contrast, the lipopeptide daptomycin requires membrane phosphatidylglycerol for activity and is only used to treat infections … Continue reading Membrane targeting drugs polymyxin and lipopeptide.

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Biofilm production and antimicrobial susceptibility pattern among urinary isolates

Urinary tract infection is the most commonly acquired bacterial infection. Bacterial biofilms play an important role in UTI and are responsible for persistent infections as well as higher antimicrobial resistance. The microorganisms in the biofilms are difficult to treat with antimicrobial agents causing public health problem.  Aerobic bacterial isolates from urine samples submitted to microbiology laboratory.The isolates were tested for biofilm formation by Congo red agar … Continue reading Biofilm production and antimicrobial susceptibility pattern among urinary isolates

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Shorter Treatment for Nonsevere Tuberculosis

Two thirds of children with tuberculosis have nonsevere disease, which may be treatable with a shorter regimen than the current 6-month regimen. The trial involving children with nonsevere, symptomatic, presumably drug-susceptible, smear-negative tuberculosis in Uganda, Zambia, South Africa, and India with under 16 years of age were randomly assigned to 16 weeks or 24 weeks of standard first-line antituberculosis treatment with pediatric fixed-dose combinations as recommended … Continue reading Shorter Treatment for Nonsevere Tuberculosis

Advances in breast cancer radiotherapy

Breast cancer is the most common cancer among women in India, and about 160,000 cases are diagnosed annually. Advances in technology, as well as our understanding of breast cancer biology, coupled with an increasing emphasis on early detection, have resulted in improved outcomes for breast cancer patients. Here, an attempt was made to review the recent advances made in adjuvant radiotherapy of breast cancer. Technological … Continue reading Advances in breast cancer radiotherapy

Visualising Viruses

Viruses pose a challenge to our imaginations. The structures of some virus particles have been determined experimentally in great detail, but for many important viruses a detailed description of the virus particle is lacking. This can be because they are challenging to describe with a single experimental method, or simply because of a lack of data. In these cases, methods from medical illustration can be applied … Continue reading Visualising Viruses

Detection of invasive Trichosporon asahii in patient blood by a fungal PCR array

Immunosuppression due to medical therapy has extended life expectancy of patients with previously fatal diseases and is therefore playing a crucial role in the increasing incidence of invasive fungal infections .  Globally, invasive trichosporonosis is reported to be the second most common non-candida yeast infection in patients suffering from haematological malignancies, oftentimes leading to fatal outcomes despite appropriate therapy . Herein, we report on a retrospectively applied experimental diagnostic fungal … Continue reading Detection of invasive Trichosporon asahii in patient blood by a fungal PCR array

Trial of Closed-Loop therapy in Young Children with Type 1 Diabetes

In this multicenter, randomized, crossover trial, we recruited children 1 to 7 years of age with type 1 diabetes who were receiving insulin-pump therapy.  Participants received treatment in two 16-week periods, in random order, in which the closed-loop system was compared with sensor-augmented pump therapy. The primary end point was between-treatment difference in the percentage of time that the sensor glucose measurement was in the … Continue reading Trial of Closed-Loop therapy in Young Children with Type 1 Diabetes

Recruitment of Project. Associate – I, At Central Food Technological Research Institute, Mysuru

Applications from eligible candidates for recruitment of 02 (Two) positions of PROJECT ASSOCIATE LEVEL – I initially for a period upto March 2022 (Extendable up to March 2023) on temporary contractual basis in the project entitled “SEED-ENDOPHYTE INTERACTION: Strategies to reduce mycotoxins (fungal secondary metabolites) in cereal grainsduring storage conditions through seed-endophyte interactions”. Essential Qualifications: M.Sc in Microbiology / Biotechnology / Biochemistry / Botany (Min. … Continue reading Recruitment of Project. Associate – I, At Central Food Technological Research Institute, Mysuru

CSIR – Indian Institute Of Chemical Technology, in search of Project Associate

CSIR – IICT Hyderabad is conducting Online Interview for the following positions under various sponsored projects purely on a temporary basis. The earlier nomenclatures for the positions of Project Associate–I is Project Assistant level II & Project-JRF and for that of Senior Project Associate is Project-RA.Position Senior Project Associate Age 40Project Associate – II Age 35Project Associate — I- Age 35 2. The above age … Continue reading CSIR – Indian Institute Of Chemical Technology, in search of Project Associate

Engagement of Project Associates/Scientific Administrative Assistants at CSIR – Central Leather Research Institute

CSIR – Central Leather Research Institute (CLRI), Chennai is a National Laboratory under the aegis of Council of Scientific & Industrial Research. It is one of the world’s premier Institute engaged in Research & Development in the area of Leather Science & Technology. Applications are invited for engagement as Senior Project Associates, Project Associates, Project Assistants and Scientific Administrative Assistants at various levels under different … Continue reading Engagement of Project Associates/Scientific Administrative Assistants at CSIR – Central Leather Research Institute