Fight against drug-resistant typhoid aided by new genomic resource

A new online resource gives the public health community the power to track antimicrobial resistance in Salmonella Typhi (S. Typhi), the bacterium that causes typhoid fever, using genomic sequencing. Improving surveillance in this way enables early interventions to minimize the spread of the disease.

The free community-driven tool called Typhi Pathogenwatch was developed by the Center for Genomic Pathogen Surveillance at the Big Data Institute, University of Oxford in conjunction with researchers at the Wellcome Sanger Institute, London School of Hygiene and Tropical Medicine, University of Cambridge, Public Health England and the International Vaccine Institute. A new article in Nature Communications details how the system works and the scope of its functionality.

Salmonella typhiTyphoid fever is a highly contagious bacterial infection that is most common in parts of the world that have poor sanitation and limited access to clean water. In 2017, more than 10 million cases and more than 110,000 deaths were estimated globally, mostly among children and adolescents in Asia and sub-Saharan Africa. S. Typhi is becoming increasingly resistant to antibiotics, particularly in low-resource settings where health support is limited. Early warning signs of antimicrobial resistance can be detected through whole genome sequencing of S. Typhi.

In the past, this kind of genome sequencing has only been possible in higher income countries and has required expert knowledge of genomics and bioinformatics. Pathogenwatch makes the genomic data rapidly accessible to a broad range of people within the public health community via a web browser, where it can be easily analyzed and disseminated. Routine surveillance using this resource, alongside whole genome sequencing, can inform decisions on treatments for typhoid fever and the introduction and impact of vaccine programs. Pathogen watch facilitates access to genomic data for public health on a global scale. The tool has the potential to sequence other infectious diseases, and has been deployed to help with the COVID-19 response by tracking variants of the SARS-CoV-2 virus.

Typhi Pathogenwatch is a partnership across the Typhi Genomics community who aim to democratize access to genomic data and technology for global public health decision making.

Danielle J. Ingle et al. Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers, PLOS Neglected Tropical Diseases (2019). DOI: 10.1371/journal.pntd.0007620

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