Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems.
FIG: Schematic drawing of the traditional vaccine/therapeutics discovery pipeline and the possibilities of retooling with 3D bioprinting technologies (gray boxes)
Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.
Yi, HG., Kim, H., Kwon, J. et al. Application of 3D bioprinting in the prevention and the therapy for human diseases. Sig Transduct Target Ther 6, 177 (2021). https://doi.org/10.1038/s41392-021-00566-8