Comparative analysis of long noncoding RNAs in angiosperms and characterization of long noncoding RNAs in response to heat stress in Chinese cabbage

Long noncoding RNAs (lncRNAs) are widely present in different species and play critical roles in response to abiotic stresses. However, the functions of lncRNAs in Chinese cabbage under heat stress remain unknown. Here, we first conducted a global comparative analysis of 247,242 lncRNAs among 37 species. The results indicated that lncRNAs were poorly conserved among different species, and only 960 lncRNAs were homologous to 524 … Continue reading Comparative analysis of long noncoding RNAs in angiosperms and characterization of long noncoding RNAs in response to heat stress in Chinese cabbage

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

Coronaviridae is a family of encapsulated single-stranded positive-sense RNA viruses that typically cause mild respiratory diseases such as the common cold in humans. However, several β coronavirus strains have emerged over the last two decades that cause acute respiratory infections associated with high mortality, particularly in individuals with underlying health conditions. Three major outbreaks have occurred, the first caused by Severe acute respiratory syndrome coronavirus … Continue reading A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

Simultaneous bioremediation of cationic copper ions and anionic methyl orange azo dye by brown marine alga Fucus vesiculosus

Textile wastewater contains large quantities of azo dyes mixed with various contaminants especially heavy metal ions. The discharge of effluents containing methyl orange (MO) dye and Cu2+ ions into water is harmful because they have severe toxic effects to humans and the aquatic ecosystem. The dried algal biomass was used as a sustainable, cost-effective and eco-friendly for the treatment of the textile wastewater. Box–Behnken design … Continue reading Simultaneous bioremediation of cationic copper ions and anionic methyl orange azo dye by brown marine alga Fucus vesiculosus

X-ray computed tomography

X-ray computed tomography (CT) can reveal the internal details of objects in three dimensions non-destructively. In this Primer, we outline the basic principles of CT and describe the ways in which a CT scan can be acquired using X-ray tubes and synchrotron sources, including the different possible contrast modes that can be exploited. We explain the process of computationally reconstructing three-dimensional (3D) images from 2D … Continue reading X-ray computed tomography

Cross-modal motion after effects transfer between vision and touch in early deaf adults

Previous research on early deafness has primarily focused on the behavioral and neural changes in the intact visual and tactile modalities. However, how early deafness changes the interplay of these two modalities is not well understood. In the current study, we investigated the effect of auditory deprivation on visuo-tactile interaction by measuring the cross-modal motion aftereffect. Consistent with previous findings, motion aftereffect transferred between vision … Continue reading Cross-modal motion after effects transfer between vision and touch in early deaf adults

Towards a consistent neuron classification

Obtaining a consistent taxonomy of neuron types is challenging mainly because of the high dimensionality of the datasets. Coupled autoencoders are a step forward in achieving this goal. Neurons in the mammalian brain are incredibly diverse: they exhibit a wide range of morphologies, connectivity patterns, molecular profiles, electrophysiological properties, plasticity-induced mechanisms, and so forth. Being able to classify this huge neuronal diversity into consistent discrete subtypes … Continue reading Towards a consistent neuron classification

Scientists call for fully open sharing of coronavirus genome data

Hundreds of scientists are urging that SARS-CoV-2 genome data should be shared more openly to help analyse how viral variants are spreading around the world. Researchers have posted huge numbers of SARS-CoV-2 genome sequences online since January 2020. The most popular data-sharing platform, called GISAID, now hosts more than 450,000 viral genomes; Soumya Swaminathan, the chief scientist at the World Health Organization (WHO), has called … Continue reading Scientists call for fully open sharing of coronavirus genome data

The next 20 years of human genomics must be more equitable and more open

The first drafts of the human genome, published in Nature and Science 20 years ago, flung open the doors for what some predicted would be ‘biology’s century’. In just one-fifth of the century, the corpus of information has grown from two gappy and error-filled genome sequences to a full account of the genetic variation of hundreds of thousands of individuals around the world, and an … Continue reading The next 20 years of human genomics must be more equitable and more open

The kinetic landscape of an RNA-binding protein in cells

Gene expression in higher eukaryotic cells orchestrates interactions between thousands of RNA-binding proteins (RBPs) and tens of thousands of RNAs1. The kinetics by which RBPs bind to and dissociate from their RNA sites are critical for the coordination of cellular RNA–protein interactions2. However, these kinetic parameters have not been experimentally measured in cells. Here we show that time-resolved RNA–protein cross-linking with a pulsed femtosecond ultraviolet … Continue reading The kinetic landscape of an RNA-binding protein in cells

Speciation and milk adulteration analysis by rapid ambient liquid MALDI mass spectrometry

Growing interest in food quality and traceability by regulators as well as consumers demands advances in more rapid, versatile and cost-effective analytical methods. Milk, as most food matrices, is a heterogeneous mixture composed of metabolites, lipids and proteins. One of the major challenges is to have simultaneous, quantitative detection (profiling) of this panel of biomolecules to gather valuable information for assessing food quality, traceability and … Continue reading Speciation and milk adulteration analysis by rapid ambient liquid MALDI mass spectrometry